The Atomic-Level Physiochemical Determinants of T Cell Receptor Dissociation Kinetics
Z. A. Rollins, J. Huang, I. Tagkopoulos, R. Faller, S. C. George
This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.
bioRxiv · Oct 25, 2021Immunology