Author

Z. A. Rollins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. C. George· 5 shared R. Faller· 3 shared B. S. Shergill· 2 shared M. B. Curtis· 2 shared V. S. Shirure· 2 shared A. Anand· 1 shared A. M. Alhassan· 1 shared A. M. Deely· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBioengineering

S. C. George

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A microfluidic strategy to capture antigen-specific high affinity B cells

A. M. Alhassan, V. S. Shirure, J. Luo, B. B. Nguyen, Z. A. Rollins, B. S. Shergill, X. Zhu, N. Baumgarth, S. C. George

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

bioRxiv · Jul 12, 2023Bioengineering

Automated protein-protein structure prediction of the T cell receptor-peptide major histocompatibility complex

Z. A. Rollins, M. B. Curtis, R. Faller, S. C. George

The paper presents a pipeline to predict TCR-pMHC structures and rank TCRs for immunotherapeutic applications using computational methods.

bioRxiv · Jun 1, 2022 · PreprintBiophysics

T Cell Receptor Non-Equilibrium Kinetics

Z. A. Rollins, R. Faller, S. C. George

This study shows that mutations in pMHC binding groove peptides affect TCR-pMHC bond strength and duration, correlating with immunogenicity through physiochemical features.

bioRxiv · Oct 27, 2021Biophysics

The Atomic-Level Physiochemical Determinants of T Cell Receptor Dissociation Kinetics

Z. A. Rollins, J. Huang, I. Tagkopoulos, R. Faller, S. C. George

This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.

bioRxiv · Oct 25, 2021Immunology

Organ-on-a-chip model of vascularized human bone marrow niches

D. E. Glaser, M. B. Curtis, P. A. Sariano, Z. A. Rollins, B. S. Shergill, A. Anand, A. M. Deely, V. S. Shirure, L. Anderson, J. M. Lowen, N. R. Ng, K. Weilbaecher, D. C. Link, S. C. George

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.

bioRxiv · Apr 17, 2020Bioengineering