Author

I. Torrecilla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. N. Singh· 2 shared B. Vaz· 2 shared K. Ramadan· 2 shared M. Popovic· 2 shared A. Kiltie· 1 shared A. Ruggiano· 1 shared D. Lessel· 1 shared D. Pilger· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

A. N. Singh

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2 papers

Recent·Most cited

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

B. Vaz, A. Ruggiano, M. Popovic, G. Rodriguez-Berriguete, S. Kilgas, A. N. Singh, I. Torrecilla, G. Higgins, A. Kiltie, K. Ramadan

This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.

bioRxiv · Feb 14, 2020 · PreprintCell Biology

SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

S. Halder, I. Torrecilla, M. Burkhalter, M. Popovic, J. Fielden, B. Vaz, J. Oehler, D. Pilger, D. Lessel, K. Wiseman, A. N. Singh, I. Vendrell, R. Fischer, M. Philipp, K. Ramadan

This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.

bioRxiv · Oct 31, 2018Cell Biology