Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures
Yasmine Iacone, Tatiana P. Morais, François David, Francis Delicata, Joanna Sandle, Tímea Raffai, H. Rheinallt Parri, Johan Juhl Weisser, Christoffer Bundgaard, Ib Vestergaard Klewe, Gábor Tamás, Morten Skøtt Thomsen, Vincenzo Crunelli, Magor L. Lörincz
This study shows that systemic ivabradine, an HCN channel inhibitor, reduces absence seizures in rats, suggesting its potential as a new treatment for this condition.
Epilepsia · May 20, 2021Peer-reviewedNeuroscience