Vincenzo Crunelli

Biphasic Modulation of Absence Seizures by Lisuride in GAERS: Dissecting the Role of 5-HT2A Receptors

This study investigates lisuride's biphasic effects on absence seizures in GAERS, showing dose-dependent modulation and distinct roles for 5-HT2A receptors in different phases.

Block of Thalamic 5-HT2A Receptors modulates Tonic GABA-A Inhibition but not Absence Seizures

The paper investigates the role of 5-HT2A receptor signaling in modulating tonic GABA-A inhibition and absence seizures in GAERS rats, finding that while it affects tonic currents, it does not alter seizure occurrence.

Heterogeneity of ictal firing during generalized seizures in the awake cortex

The paper examines cortical neuron firing patterns during absence seizures in awake rodents, finding structured heterogeneity rather than generalized hyperexcitability.

Cortico-thalamic excitatory-inhibitory dynamics generates α-wave transient patterns encoding anesthetic brain states

This paper uses in vivo recordings and a neural mass model to show how thalamocortical excitatory-inhibitory dynamics generate α-wave patterns during anesthesia, linking EEG oscillations to network dynamics.

Sleep waves in a large-scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons

The paper builds a corticothalamic model that reproduces EEG sleep rhythms by incorporating intrinsic abilities of neocortical networks and thalamic neurons to generate sleep waves.

Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic model

This paper simulates spike-and-wave discharges in a corticothalamic model to study absence seizures, finding specific channel abnormalities lead to different seizure frequencies.

Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges in absence seizures

This study investigates how higher-order thalamic nuclei contribute to the spread and maintenance of spike-and-wave discharges in absence seizures using GAERS models.

Decreased overall neuronal activity in a rodent model of impaired consciousness during absence seizures

The paper investigates neuronal activity patterns in a rodent model of absence seizures, finding decreased overall firing with distinct neuronal activity patterns during seizures.

Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in GAERS and NEC rats

This study shows that the cannabinoid agonist WIN 55,212-2 has strain-dependent effects on anxiety and motor behavior, along with monoaminergic changes, in GAERS and NEC rats.

Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures

This study shows that systemic ivabradine, an HCN channel inhibitor, reduces absence seizures in rats, suggesting its potential as a new treatment for this condition.

Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency

This study examines information processing deficits in a mouse model of Ehmt1 haploinsufficiency, showing abnormalities in sensory-motor gating and electrophysiological responses.