The signaling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence.
Natalia García-Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, S. Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto
This paper shows dinaciclib increases radiosensitivity in some cancer cell lines by inhibiting CDK12, reducing BRCA1, and promoting p53-dependent senescence.
Molecular Oncology · Dec 3, 2024Peer-reviewedCancer Biology