Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice
Yuichi Maeda, Miriam Rabenow, Wei Xiang, Eva Schmid, Nadine Otterbein, Ilia Gimaev, Lena Amend, Lena Riedinger, Leona Ehnes, Ippei Miyagawa, Ilann Sarfati, Till Robin Lesker, Heike Danzer, Kerstin Sarter, Kerstin Dürholz, , Mario M. Zaiss
This study shows that Prevotella intestinalis induces arthritis in resistant mice by activating intestinal immune cells and promoting Th17 differentiation through IL-6.
Cell Reports · Jan 1, 2026Peer-reviewedImmunology