Microbiota-specific serum IgG links gut and joints through immune-endothelial crosstalk in arthritis
Eva Schmid, Nadine Otterbein, Stephen Ariyeloye, Heike Danzer, Michael Frech, Elisabeth Naschberger, Marco Muñoz‐Becerra, Kerstin Sarter, Georg Andreas Schett, Alf Kastbom, Anna Svärd, Ben Wielockx, Mario M. Zaiss
This study identifies microbiota-specific serum IgG as a mediator of gut-joint immune-endothelial crosstalk in arthritis, showing its role in initiating autoimmunity through endothelial barrier impairment and microbial translocation.
Frontiers in Microbiology · May 20, 2026Peer-reviewedImmunology