Till Robin Lesker

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

Interleukin-17A Mediates Cardiorenal Injury In Oxalate Nephropathy

This study identifies IL-17A as a mediator of oxalate-induced cardiorenal injury in CKD, showing its role in inflammation and cardiac dysfunction.

Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice

This study shows that Prevotella intestinalis induces arthritis in resistant mice by activating intestinal immune cells and promoting Th17 differentiation through IL-6.

Metabolites produced by gut bacteria under anoxic conditions drive the suppression of Acinetobacter baumannii

The paper shows that gut bacteria like Klebsiella oxytoca, under anoxic conditions, suppress Acinetobacter baumannii through metabolites from specific carbohydrates like maltose.

Gene-centric metagenomic analyses reveal microbiome functional insights into diseases

The paper develops MetaGEAR, a gene-centric metagenomic analysis framework, to investigate microbiome functionality in diseases and identify disease signature genes and mobile genetic elements.

The RNA landscape of the human commensal Segatella copri reveals a small RNA essential for gut colonization

This study identifies a small RNA, SrcF, essential for gut colonization of Segatella copri, regulated by complex carbohydrates and influenced by the human microbiome.

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19

This study links gut microbiota dysbiosis and altered tryptophan metabolism to increased inflammation in severe COVID-19 patients.

Critical Assessment of Metagenome Interpretation - the second round of challenges

The paper evaluates metagenomic software tools using realistic datasets, highlighting improvements in assembly and taxon profiling while identifying remaining challenges in virus/archaea detection and reproducibility.

Haploflow: Strain-resolved de novo assembly of viral genomes

Haploflow assembles viral strain genomes from mixed samples, outperforming existing assemblers in speed and accuracy on benchmark datasets.

CAMISIM: Simulating metagenomes and microbial communities

CAMISIM simulates microbial communities and metagenomes with truth standards, enabling benchmarking of metagenomic analysis tools.

Nucleotide-pair encoding of 16S rRNA sequences for host phenotype and biomarker detection

This paper introduces DiTaxa, a method for analyzing 16S rRNA sequences using nucleotide-pair encoding to improve microbiome phenotype classification and biomarker detection.