A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes
Matthew J. Witney, Nathan P. Croft, Michael Yik-Chun Wong, Stewart A. Smith, Inge E. A. Flesch, E. Keller, Leon C. W. Lin, Yanli Li, Nicole L. La Gruta, Anthony Wayne Purcell, David C. Tscharke
This study quantifies antigen presentation kinetics and immunogenicity of viral epitopes during poxvirus infection, revealing that epitope levels correlate with immunogenicity only when measured ex vivo.
Science Advances · Dec 19, 2025Peer-reviewedImmunology