Author

Matthew J. Witney

Australian National UniversityORCID 0000-0002-0939-710XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Anthony Wayne PurcelliD· 2 shared David C. TscharkeiD· 1 shared E. KelleriD· 1 shared Feng WangiD· 1 shared Inge E. A. Flesch· 1 shared Jamie RossjohniD· 1 shared Jiangning SongiD· 1 shared Leon C. W. LiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Anthony Wayne PurcellORCID

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2 papers

Recent·Most cited

Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model

Yumeng Zhang, Wenhua Liang, 许舒婷, Matthew J. Witney, Xiao‐Dong Su, Miles C Andrews, Jamie Rossjohn, Anthony Wayne Purcell, Feng Wang, Jiangning Song

This paper introduces TCRDiff, a conditional diffusion model for generating antigen-specific TCR sequences, validated through in vitro assays.

bioRxiv · Jul 1, 2026 · PreprintBioinformatics

A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes

Matthew J. Witney, Nathan P. Croft, Michael Yik-Chun Wong, Stewart A. Smith, Inge E. A. Flesch, E. Keller, Leon C. W. Lin, Yanli Li, Nicole L. La Gruta, Anthony Wayne Purcell, David C. Tscharke

This study quantifies antigen presentation kinetics and immunogenicity of viral epitopes during poxvirus infection, revealing that epitope levels correlate with immunogenicity only when measured ex vivo.

Science Advances · Dec 19, 2025Peer-reviewedImmunology