VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia
Olesya Plazyo, Laura B. Chopp, Rishyanth Peela, Kelly Z. Young, Haihan Zhang, Rachael Wasikowski, Ashley Hesson, Elizabeth Suzanne Langen, Ingrid L Bergin, Li-Jyun Syu, Jake Erba, Joseph Kirma, Poulami Dey, Lin Zhang, Mrinal K. Sarkar, , Johann Eli Gudjonsson
This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.
bioRxiv · May 30, 2025 · PreprintImmunology