Loopsim performs enrichment analysis on Hi-C loop profiles by simulating empirical null distributions to assess statistical significance of loop features.

NAR Genomics and Bioinformatics · Jul 4, 2025Peer-reviewedBioinformatics

TWEAK Signaling Drives the Transition from Psoriasis to Atopic Dermatitis-like Inflammation in Paradoxical Skin Reactions

Sahiti Marella, Rachael Wasikowski, Haihan Zhang, Jennifer P. Fox, Joseph Kirma, Xianying Xing, Benjamin Klein, Vincent van Drongelen, Zoey Feister, Fadia Zagairy, Mira Hamed, Rundong Jiang, Poulami Dey, Joanne Michelle Kahlenberg, Allison C. Billi, , Eran Cohen‐Barak

The paper identifies TWEAK-IL-13 signaling as a driver of paradoxical skin reactions following anti-TNF, IL-17, or IL-23 therapy.

bioRxiv · Jun 19, 2025 · PreprintImmunology

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

Olesya Plazyo, Laura B. Chopp, Rishyanth Peela, Kelly Z. Young, Haihan Zhang, Rachael Wasikowski, Ashley Hesson, Elizabeth Suzanne Langen, Ingrid L Bergin, Li-Jyun Syu, Jake Erba, Joseph Kirma, Poulami Dey, Lin Zhang, Mrinal K. Sarkar, , Johann Eli Gudjonsson

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

bioRxiv · May 30, 2025 · PreprintImmunology