SAMD1 suppresses epithelial-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma
Clara Simon, Inka D. Brunke, Bastian Stielow, Ignasi Forné, Anna Mary Steitz, Merle Geller, Iris Rohner, Lisa Marie Weber, Sabrina Fischer, Lea Marie Jeude, Theresa Huber, Andrea Nist, Thorsten Stiewe, Magdalena Huber, Malte Buchholz, Robert Liefke
This study identifies SAMD1 as a repressor of EMT-related genes in PDAC, showing that its loss increases migration and that FBXO11 ubiquitinates SAMD1 to inhibit its function.
PLoS Biology · Aug 13, 2024Peer-reviewedMolecular Biology