Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation
Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kärt Mätlik, Elizabeth G. Poulsen Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin Aaron Garcia, C. David Allis
This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.
bioRxiv · Sep 29, 2023 · PreprintMolecular Biology