Douglas Barrows

This study investigates the thermogenic adaptations of antelope ground squirrels by analyzing their genome and transcriptome under cold exposure, revealing a shift toward shivering thermogenesis.

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

This study identifies epigenetic mechanisms linking cell type-specific enhancer activity to somatic CAG expansion and toxicity in Huntington's disease.

This study shows that acetylation of MED1's IDR affects PIC assembly, chromatin organization, and gene expression in ER+ breast cancer cells.

This study shows that ATRX loss in mesenchymal progenitor cells leads to aberrant differentiation by altering chromatin structure and gene regulation.

This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.