Liangwen Zhong

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

The paper investigates how Lamin A/C influences chromatin structure during early mammalian lineage segregation, showing its role in maintaining trophectoderm identity.

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.

A Spatiotemporal Compartmentalization of Glucose Metabolism Guides Mammalian Gastrulation Progression

This study identifies how distinct glucose metabolic pathways guide spatial and temporal aspects of mouse gastrulation, linking metabolism to cell fate and morphogenesis.

Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells

The paper shows that adding lipid-rich albumin to 2i media maintains genomic stability and developmental potency of murine pluripotent stem cells over long-term culture.

Generation of clonal male and female mice through CRISPR/Cas9-mediated Y chromosome deletion in embryonic stem cells

This paper describes a method to generate clonal male and female mice using CRISPR/Cas9 to delete the Y chromosome in embryonic stem cells, enabling tetraploid complementation to produce viable mice.