Duancheng Wen

The paper investigates how maternal H3.3 contributes to paternal genome reprogramming and minor zygotic genome activation in mice.

The paper demonstrates that lipid-rich 2iLA medium enables the generation of ERas-null all-ESC mice, revealing a novel role for ERas in craniofacial development.

This study identifies an asymmetric distribution of oocyte-specific H3.3 during early embryonic development, leading to differential maternal genome activation in blastomeres.

This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.

The paper shows that adding lipid-rich albumin to 2i media maintains genomic stability and developmental potency of murine pluripotent stem cells over long-term culture.

This paper describes a method to generate clonal male and female mice using CRISPR/Cas9 to delete the Y chromosome in embryonic stem cells, enabling tetraploid complementation to produce viable mice.