Inhibition of translation termination by Drosocin, an antimicrobial peptide from fruit flies
Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu, Chetana Baliga, Weiping Huang, Alexandra Brakel, Andor Krizsan, Yury S. Polikanov, Ralf Hoffmann, Nora Vázquez‐Laslop, Alexander S. Mankin
This study identifies Drosocin as a type II PrAMP that inhibits protein synthesis termination by stalling ribosomes at stop codons, distinct from apidaecin.
bioRxiv · Dec 11, 2022 · PreprintMolecular Biology