Tissular glucocorticoid reactivating enzyme 11beta-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease
Grégoire Arnoux, David Legouis, Matthieu Tihy, Raphaël Yvon, Nicolas Liaudet, Seraina O. Moser, Hélène Poinot, Ali Sassi, Olga M. Lempke, Marylise Fernandez, Isabelle Monnay, Alexandra Chassot, Carole Bourquin, Solange Moll, Emmanuel Somm, , Eric Féraille
This study identifies 11beta-HSD1 as a driver of myofibroblast differentiation in CKD, showing its inhibition reduces fibrosis and improves renal function.
bioRxiv · Jan 9, 2025 · PreprintPhysiology