Author

Isobel E. Bowles

Dartmouth College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Alejandro GutierreziD· 1 shared Anais Torres· 1 shared Esteban A. OrellanaiD· 1 shared Jane E. JackmaniD· 1 shared Raja Hussain AliiD· 1 shared Richard I. GregoryiD· 1 shared Sally Jamieson· 1 shared Xin YangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alejandro GutierrezORCID

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2 papers

Recent·Most cited

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis

Esteban A. Orellana, Isobel E. Bowles, Xin Yang, Anais Torres, Sally Jamieson, Raja Hussain Ali, Alejandro Gutierrez, Richard I. Gregory

This study identifies tRNA-Arg-TCT-4-1 as a new anti-cancer therapeutic target and shows that targeting it with an ASO suppresses tumorigenesis and extends survival in mouse models.

bioRxiv · Feb 20, 2026 · PreprintCancer Biology

A tRNA-specific function for tRNA methyltransferase Trm10 is associated with a new tRNA quality control mechanism in Saccharomyces cerevisiae

Isobel E. Bowles, Jane E. Jackman

The paper identifies a specific role for Trm10-mediated m1G9 modification in tRNATrp quality control in yeast, showing it is essential for tRNATrp function and subject to a distinct quality control mechanism.

RNA · Dec 8, 2023Peer-reviewedMolecular Biology