Author

Esteban A. Orellana

Dartmouth CollegeORCID 0000-0003-4369-9416Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Ahmed M. Abdelaal· 1 shared Alejandro GutierreziD· 1 shared Anais Torres· 1 shared Andrea L. KasinskiiD· 1 shared Isobel E. Bowles· 1 shared Loganathan RangasamyiD· 1 shared Philip Stewart LowiD· 1 shared Raja Hussain AliiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Ahmed M. Abdelaal

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 20, 2026

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis

Esteban A. Orellana, Isobel E. Bowles, Xin Yang…·Richard I. Gregory

This study identifies tRNA-Arg-TCT-4-1 as a new anti-cancer therapeutic target and shows that targeting it with an ASO suppresses tumorigenesis and extends survival in mouse models.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewedApr 11, 2019

Enhancing microRNA activity through increased endosomal release mediated by nigericin

Esteban A. Orellana, Ahmed M. Abdelaal, Loganathan Rangasamy…·Andrea L. Kasinski

This paper develops a method to enhance miRNA activity by promoting endosomal escape using nigericin and folate ligands, enabling cytoplasmic delivery and RNAi activation.

39 citations

experimental assay

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