Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease
Rebecca Roddan, Matthew A. Schaich, William J. Nathan, Iulia Kis, Andrea Pierangelini, Lucy R. Henderson, Raman van Wee, Louise Martin, Afaf Helmy El-Sagheer, Philipp Kukura, Tom P Brown, Darragh Patrick O'Brien, Joseph A. Newman, David M. Wilson, Christopher John Schofield, , Peter J. McHugh
This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.
bioRxiv · Sep 5, 2024 · PreprintBiochemistry