Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration
Ye Yao, Yujia Li, Chenjun Huang, Jiayi Ma, Liang Xu, Stephanie D. Wolf, Julian Gilljam, Haifeng Zeng, Stefan Munker, Xioachun Cao-Ehlker, Ruochan Li, Bernhard Willibald Renz, Hanno Nieß, Seddik Hammad, Elisa Holstein, , Sai Wang
This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.
bioRxiv · Jun 10, 2026 · PreprintCell Biology