Chunfang Gao

Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regeneration

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.