Author

Jürgen Groet

Queen Mary University of London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

André StrydomiD· 2 shared Carla Marie StartiniD· 2 shared Dean NižetićiD· 2 shared Henrik ZetterbergiD· 2 shared John HardyiD· 2 shared Kin Ying MokiD· 2 shared Agueda A. RostagnoiD· 1 shared Amanda HeslegraveiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

André StrydomORCID

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2 papers

Recent·Most cited

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Ying Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh Louise O’Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, Norris Ray Dunn, , Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

Molecular Psychiatry · Jul 9, 2020Peer-reviewedNeuroscience

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

André Strydom, Amanda Heslegrave, Carla Marie Startin, Kin Ying Mok, John Hardy, Jürgen Groet, Dean Nižetić, Henrik Zetterberg

This study shows that neurofilament light (NF-L) levels in blood increase with age and predict dementia in adults with Down syndrome, suggesting its potential as a non-invasive biomarker for neurodegeneration.

Alzheimer s Research & Therapy · Apr 10, 2018Peer-reviewedMolecular Biology