Senescence of alveolar stem cells drives progressive pulmonary fibrosis
C. Yao, X. Guan, G. Carraro, T. Parimon, X. Liu, G. Huang, H. Soukiasian, G. David, S. S. Weight, J. A. Belperio, P. Chen, D. Jiang, P. W. Noble, B. R. Stripp
This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.
bioRxiv · Nov 18, 2019 · PreprintCell Biology