Author

P. W. Noble

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

C. Yao· 4 shared D. Jiang· 4 shared X. Liu· 4 shared G. Huang· 3 shared J. Liang· 3 shared P. Chen· 3 shared A. Burman· 2 shared B. R. Stripp· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

C. Yao

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5 papers

Recent·Most cited

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungs

X. Liu, X. Zhang, C. Yao, J. Liang, P. W. Noble, D. Jiang

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.

bioRxiv · Jun 16, 2023 · PreprintCell Biology

cGAS-activating lupus autoantibody for cancer immunotherapy

X. Chen, X. Tang, B. J. Cuffari, C. Tang, X. Gao, P. W. Noble, M. R. Young, O. M. Turk, A. Shirali, J. Gera, R. N. Nishimura, J. Zhou, J. E. Hansen

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

bioRxiv · Feb 11, 2023 · PreprintImmunology

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

J. Liang, G. Huang, X. Liu, F. Taghavifar, N. Liu, C. Yao, N. Deng, Y. Wangy, A. Burman, T. Xie, S. C. Rowan, P. Chen, C. M. Hogaboam, B. Stripp, S. S. Weigt, , D. Jiang

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

bioRxiv · Jul 30, 2020Cell Biology

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

X. Liu, S. C. Rowan, J. Liang, C. Yao, G. Huang, N. Deng, T. Xie, D. Wu, Y. Wang, A. Burman, T. Parimon, Z. Borok, P. Chen, W. C. Parks, C. M. Hogaboam, , D. Jiang

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

bioRxiv · Jul 15, 2020 · PreprintCell Biology

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

C. Yao, X. Guan, G. Carraro, T. Parimon, X. Liu, G. Huang, H. Soukiasian, G. David, S. S. Weight, J. A. Belperio, P. Chen, D. Jiang, P. W. Noble, B. R. Stripp

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.

bioRxiv · Nov 18, 2019 · PreprintCell Biology