G. Huang

Defect-Engineered Metal-Organic Frameworks as Nanocarriers for Pharmacotherapy: Insights into Intracellular Dynamics at The Single Particle Level

This study tracks single nanoMOFs in live cells to understand their intracellular dynamics and internalization pathways using fluorescence and machine learning.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

Auditory High Entropy Response (A-HER): A Novel Paradigm for Studying Brain Processing of Uncertain Information

The paper introduces A-HER, a paradigm that maximizes auditory stimulus entropy to study brain processing of uncertain information, showing improved signal-to-noise ratio and repeatability compared to other methods.

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

This study develops a genetically encoded biosensor to measure intracellular NMN dynamics in live cells and identifies Slc25a45 as a potential mitochondrial NMN transporter.

WBSCR16 Determines Metabolic Flexibility Via Regulating Mitochondrial 16S rRNA Maturation

This study identifies WBSCR16 as a key regulator of metabolic flexibility by controlling mitochondrial 16S rRNA maturation and switching between glucose and lipid metabolism.

Reciprocal polarization imaging of complex media.

This paper introduces reciprocal polarization imaging to quantify anisotropic properties of complex media using backscattering Mueller matrices, demonstrating its effectiveness in various applications.

Sensitivity-enhanced magnetic resonance reveals hydrogen intermediates during active -hydrogenase catalysis

This study uses sensitivity-enhanced magnetic resonance to identify new hydrogen species in [Fe]-hydrogenase catalysis, advancing understanding of hydrogen metabolism and catalyst design.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

Extracellular matrix stiffness regulates fibroblast differentiation by influencing DNA methyltransferase 1 expression through microtubule polymerization

This study shows that extracellular matrix stiffness influences fibroblast differentiation by modulating DNMT1 expression via microtubule polymerization.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

A Self-Healing, Viscoelastic Hydrogel Promotes Healing of Brain Lesions

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

Immunological findings in a group of individuals who were non-responders to standard two-dose SARS-CoV-2 vaccines

The paper compares immunological characteristics of SARS-CoV-2 vaccine non-responders aged 18-59 and 60+ to identify factors associated with seroconversion and recommend booster vaccinations.

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

Near atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex

The paper determines the near-atomic structure of the Saccharomyces cerevisiae nuclear pore complex inner ring, revealing its assembly and functional dynamics.

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32

The paper presents cryo-EM structures of yeast TRAPPII complex in apo and Ypt32-bound states, revealing its assembly mechanism and specific activation of Ypt31/Ypt32.

Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates.

The paper identifies a conserved 14aa sequence in ataxin-2 that acts as a condensation switch and reveals poly(A)-binding proteins as RNA-dependent chaperones that regulate this switch.

Cross-Individual Affective Detection Using EEG Signals with Audio-Visual Embedding

This paper introduces EEG-AVE, a model that combines EEG signals with audio-visual data to improve cross-individual affective detection performance.

1,25(OH)2D3 attenuates hepatic insulin resistance in rats with streptozotocin -induced diabetes via antioxidation

This study shows that 1,25(OH)2D3 reduces hepatic insulin resistance in diabetic rats by improving antioxidant status and enhancing AKT/GLUT2 expression.

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

Bottom-up fabrication of a multi-component nanopore sensor that unfolds, processes and recognizes single proteins

This paper describes the fabrication of a multi-component nanopore sensor that unfolds, processes, and recognizes single proteins using a 28-component proteasome-nanopore complex.

Mechanical Efficiency Investigation of an ankle-assisted robot for human walking with a backpack-load

This study evaluates the mechanical efficiency of an ankle-assisted robot during walking with varying loads, finding that efficiency decreases as device weight increases.

Extraction and Characterization of Rice Bran Polysaccharides and Their Derivative Preparation and Antioxidant Activity

The paper extracts rice bran polysaccharides under optimized conditions, characterizes their derivatives, and evaluates their antioxidant activity, finding that phosphorylated derivatives show good activity.

Transient K+ current explains cross-species differences in the effects of myofibroblasts on myocytes

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis

The paper identifies a zinc metabolic defect in alveolar progenitor cells in IPF and aged mice, linked to impaired renewal and fibrosis through ZIP8 downregulation.

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.