B. R. Stripp

A potential acoustic role for CFTR ion channel in conductive hearing loss

This study investigates the role of CFTR in conductive hearing loss by analyzing middle ear cell composition and gene expression in CF and WT mice.

Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

This study compares the transcriptomes of primary, cultured, and iPSC-derived human alveolar type 2 cells to assess how culture affects their gene expression profiles and maturation states.

Cryobanking of human distal lung epithelial cells for preservation of their phenotypic and functional characteristics.

This study describes a cryobanking method that preserves phenotypic and functional characteristics of human distal lung epithelial cells, including alveolar type 2 pneumocytes.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response

This study shows that cigarette smoke exposure increases SARS-CoV-2 infection severity in airway cultures by reducing interferon response and ABSC proliferation.

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.