J. A. Kuhn

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity

This study identifies cytoskeletal feedback loops that regulate Ras/PI3K signaling and cell polarity in Dictyostelium and neutrophils by modulating actin and myosin dynamics.

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner to control cell cycle progression

The paper investigates how mammalian kinetochores detect microtubule attachments to control the SAC, finding that they respond specifically and switch-like to microtubule binding.

Spindle assembly checkpoint satisfaction occurs through end-on but not lateral kinetochore-microtubule interactions under tension

The paper shows that SAC satisfaction in mitosis depends on end-on kinetochore-microtubule attachments generating tension, not lateral attachments, which can maintain tension but do not trigger SAC silencing.