S. Dumont

Torques within and outside the human spindle balance twist at anaphase

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction

The paper shows that long chromosomes experience delayed error correction during mitosis due to increased polar ejection force, which can falsely stabilize incorrect attachments.

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force

This study shows cyclin D1 overexpression increases spindle abnormalities but protects against pole fracture under compressive force, potentially aiding cancer cell survival in solid tumors.

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

This study investigates how mammalian spindle length is maintained by showing that kinetochore-fibers can self-regulate their length without pole-focusing forces, but poles coordinate length across fibers.

Cytoplasmic divisions without nuclei

The paper shows that cytoplasmic divisions can occur without nuclei in fruit fly embryos, autonomously of the cell cycle, and are used to extrude delayed nuclei.

Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

The paper models k-fiber anchorage in mammalian spindles and shows that spatially regulated anchorage creates distinct mechanical behaviors.

The Astrin/SKAP Complex Reduces Friction at the Kinetochore-Microtubule Interface

The paper investigates the role of the Astrin-SKAP complex in reducing friction at the kinetochore-microtubule interface, enhancing attachment dynamics and force responsiveness.

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

Opposing motors provide mechanical and functional robustness in the human spindle

This study shows that opposing motors dynein and Eg5 are essential for the mechanical and functional robustness of human spindles, even though their inhibition allows bipolar spindle formation.

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics

This study shows NuMA has a spindle-independent role in forming a single, round nucleus by maintaining chromosomal compactness and nuclear mechanics.

Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure

This study uses microneedles to apply force to kinetochore-fibers and shows how they dissipate force to maintain spindle structure.

Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

The paper uses microneedle manipulation to study spindle reinforcement, finding short-lived, specialized structures near chromosomes that require PRC1.

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner to control cell cycle progression

The paper investigates how mammalian kinetochores detect microtubule attachments to control the SAC, finding that they respond specifically and switch-like to microtubule binding.

NuMA Targets Dynein to Microtubule Minus-Ends at Mitosis

The paper shows NuMA targets dynactin to microtubule minus-ends, enabling dynein to cluster microtubules into spindle poles during mitosis.

Spindle assembly checkpoint satisfaction occurs through end-on but not lateral kinetochore-microtubule interactions under tension

The paper shows that SAC satisfaction in mitosis depends on end-on kinetochore-microtubule attachments generating tension, not lateral attachments, which can maintain tension but do not trigger SAC silencing.

Mapping load-bearing in the mammalian spindle reveals local kinetochore-fiber anchorage that provides mechanical isolation and redundancy

The paper maps load-bearing in the mammalian spindle and identifies local kinetochore-fiber anchorage mechanisms that provide mechanical isolation and redundancy.