Author

P. A. Iglesias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 7 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 5 Organism:mouse· 4 Assay:proteomics· 3 Approach:statistical model· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. N. Devreotes· 5 shared D. Biswas· 3 shared D. S. Pal· 3 shared P. Banerjee· 3 shared T. Banerjee· 3 shared Y. Miao· 3 shared D. N. Robinson· 2 shared A. D. Gregory· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCell Biology

P. N. Devreotes

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity

J. A. Kuhn, P. Banerjee, A. Haye, D. N. Robinson, P. A. Iglesias, P. N. Devreotes

This study identifies cytoskeletal feedback loops that regulate Ras/PI3K signaling and cell polarity in Dictyostelium and neutrophils by modulating actin and myosin dynamics.

bioRxiv · Feb 13, 2024Cell Biology

Ras-mediated homeostatic control of front-back signaling dictates cell polarity

Y. Lin, D. S. Pal, P. Banerjee, T. Banerjee, G. Qin, Y. Deng, J. Borleis, P. A. Iglesias, P. Devreotes

This study uses optogenetics to show that RasGAPs regulate cell polarity by enhancing actomyosin contractility at the back and F-actin polymerization at the front.

bioRxiv · Aug 30, 2023Cell Biology

A dynamic partitioning mechanism polarizes membrane protein distribution

T. Banerjee, S. Matsuoka, D. Biswas, Y. Miao, D. S. Pal, Y. Kamimura, M. Ueda, P. N. Devreotes, P. A. Iglesias

This study identifies a dynamic partitioning mechanism that explains asymmetric membrane protein distribution during signaling events.

bioRxiv · Jan 3, 2023Cell Biology

Nanotopography modulates intracellular excitable systems through cytoskeleton actuation

Q. Yang, Y. Miao, P. Banerjee, M. J. Hourwitz, M. Hu, Q. Qing, P. A. Iglesias, P. N. Devreotes, J. T. Fourkas, W. Losert

The paper shows nanotopography is sensed directly by cytoskeletal networks, with implications for texture sensing and guidance cues in microenvironments.

bioRxiv · Jun 9, 2022 · PreprintBiophysics

Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration

T. Banerjee, D. Biswas, D. S. Pal, Y. Miao, P. A. Iglesias, P. N. Devreotes

This study shows that surface charge regulation on the plasma membrane integrates signaling networks to control cell polarity and migration through dynamic changes in phospholipid composition.

bioRxiv · May 19, 2022Cell Biology

3D stochastic simulation of chemoattractant-mediated excitability in cells

D. Biswas, P. N. Devreotes, P. A. Iglesias

This paper uses 3D stochastic simulations to model chemoattractant-mediated excitability in cells, showing that noise-driven excitable systems underlie pseudopod formation and migration, with implications for understanding directed cell movement.

bioRxiv · Feb 17, 2021Cell Biology

Highly multiplexed imaging of biosensors in live cells

J.-M. Yang, W.-Y. Chi, J. Liang, P. A. Iglesias, C.-H. Huang

This paper develops barcoding proteins to enable highly multiplexed imaging of biosensors in live cells by computationally unmixing signals from different biosensors.

bioRxiv · Dec 11, 2020 · PreprintCell Biology

Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function

C. Kliment, J. M. K. Nguyen, M. J. Kaltreider, Y.-W. Lu, S. M. Claypool, J. E. Radder, F. C. Sciurba, Y. Zhang, A. D. Gregory, P. A. Iglesias, V. K. Sidhaye, D. N. Robinson

This study identifies Adenine Nucleotide Translocase (ANT) as a protective factor against cigarette smoke in lung cells, showing its role in mitochondrial metabolism, airway hydration, and ciliary function in COPD.

bioRxiv · May 18, 2020 · PreprintCell Biology