Phase-separated nuclear bodies of nucleoporin fusions, SET-NUP214 and NUP98-HOXA9, promote condensation of MLL1 and CRM1 to activate target genes
M. Oka, M. Otani, Y. Miyamoto, J. Adachi, T. Tomonaga, M. Asally, Y. Ohkawa, Y. Yoneda
This study shows that nucleoporin fusions form phase-separated nuclear bodies that enhance gene activation by condensing MLL1 and CRM1 at target loci.
bioRxiv · May 24, 2022 · PreprintCell Biology