Author

J. B. Jastrab

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

K. H. Darwin· 2 shared A. Dhabaria· 1 shared A. Kovach· 1 shared B. Ueberheide· 1 shared C. Chaton· 1 shared G. Zhao· 1 shared H. Li· 1 shared J. Rush· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

K. H. Darwin

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2 papers

Recent·Most cited

The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system

S. H. Becker, J. B. Jastrab, A. Dhabaria, C. Chaton, J. Rush, K. V. Korotkov, B. Ueberheide, K. H. Darwin

This study shows that the M. tuberculosis proteasome system regulates nitrate metabolism by controlling chaperonin gene expression through proteasome-mediated degradation of HrcA.

bioRxiv · Nov 14, 2018Microbiology

Proteasome Substrate Capture and Gate Activation by Mycobacterium tuberculosis PafE

K. Hu, J. B. Jastrab, S. Zhang, A. Kovach, G. Zhao, K. H. Darwin, H. Li

This study identifies PafE as an ATP-independent proteasome activator in M. tuberculosis, revealing its mechanism of substrate capture and gate activation through structural and functional analyses.

bioRxiv · Jan 16, 2018Biochemistry