K. V. Korotkov

Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

This study characterizes the heterogeneity of the T7SS in GBS and shows subtype-specific effects on host colonization and gene expression.

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

This study identifies PplD as a de-N-acetylase that modifies the cell wall linkage unit of streptococcal rhamnopolysaccharides, enhancing resistance to host antimicrobial proteins.

Development and validation of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3)

This paper develops and validates nanobodies that specifically target PRL-3, showing high specificity over PRL-1 and PRL-2 and providing tools to study PRL-3 function in cancer.

Modification of cell wall polysaccharide spatially controls cell division in Streptococcus mutans

This study shows that GroP-deficient immature SCCs spatially coordinate AtlA and MapZ localization in S. mutans, ensuring proper cell division and morphology.

PE5-PPE4-EspG3 trimer structure from mycobacterial ESX-3 secretion system gives insight into cognate substrate recognition by ESX systems

The paper presents the crystal structure of a PE5-PPE4-EspG3 trimer from the ESX-3 system, revealing unique interactions and structural dynamics compared to the ESX-5 system.

Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site

The paper determines the crystal structures of three homoserine transacetylases and identifies MtMetX as highly druggable.

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

The paper identifies a glycerol phosphate modification on streptococcal rhamnose polysaccharides, revealing its role in host-pathogen interactions and vaccine design.

The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system

This study shows that the M. tuberculosis proteasome system regulates nitrate metabolism by controlling chaperonin gene expression through proteasome-mediated degradation of HrcA.

Structural variability of EspG chaperones from mycobacterial ESX-1, ESX-3 and ESX-5 type VII secretion systems

The paper reports crystal and SAXS structures of EspG chaperones from mycobacterial ESX systems, revealing structural variability and potential substrate binding modes.

The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A Carbohydrate in Streptococcus pyogenes