Author

K. H. Darwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. Pironti· 3 shared N. M. Samhadaneh· 3 shared S. H. Becker· 3 shared A. Dhabaria· 2 shared B. Ueberheide· 2 shared D. I. Kotov· 2 shared G. Limon· 2 shared H. Li· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

A. Pironti

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis

S. C. Kahne, J. H. Yoo, J. Chen, K. Nakedi, L. M. Iyer, G. Putzel, N. M. Samhadaneh, A. Pironti, L. Aravind, D. C. Ekiert, G. Bhabha, K. Y. Rhee, K. H. Darwin

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

bioRxiv · Mar 29, 2024 · PreprintMicrobiology

Characterization of a cytokinin-binding protein locus in Mycobacterium tuberculosis

K. H. Darwin, J. H. Yoo, C. Santarossa, A. K. Thomas, D. Ekiert

The paper identifies a cytokinin-binding protein in M. tuberculosis and shows it binds cytokinins with high specificity, suggesting cytokinins may have roles in mycobacterial physiology.

bioRxiv · Mar 25, 2024 · PreprintMicrobiology

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

S. Espich, S. Berry, X. Chang, A. Balakhmet, N. T. T. Thuong, R. Dorajoo, C. C. Khor, C. K. Heng, J.-M. Yuan, W.-P. Koh, D. Fox, A. Anaya-Sanchez, L. Tenney, C. J. Chang, R. Baral, , S. A. Stanley

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

Aldehyde accumulation in Mycobacterium tuberculosis with defective proteasomal degradation results in copper sensitivity

G. Limon, N. M. Samhadaneh, A. Pironti, K. H. Darwin

This study shows aldehyde accumulation in M. tuberculosis with defective proteasomal degradation causes copper sensitivity by impairing copper resistance proteins.

bioRxiv · Feb 11, 2023 · PreprintMicrobiology

Aldehyde inactivation of the RicR regulon sensitizes Mycobacterium tuberculosis to copper

G. Limon, N. M. Samhadaneh, A. Pironti, K. H. Darwin

This study shows aldehyde accumulation in M. tuberculosis mutants impairs the RicR regulon, increasing copper sensitivity, and suggests aldehydes may be a host defense mechanism against tuberculosis.

bioRxiv · Sep 30, 2022 · PreprintMicrobiology

Mycobacterium tuberculosis Rv0991c is a redox-regulated molecular chaperone

S. H. Becker, K. Ulrich, A. Dhabaria, B. Ueberheide, W. N. Beavers, E. P. Skaar, L. M. Iyer, L. Aravind, U. Jakob, K. H. Darwin

This paper identifies Rv0991c in M. tuberculosis as a redox-regulated molecular chaperone essential for virulence, functioning similarly to Hsp33 in E. coli.

bioRxiv · Mar 5, 2020Microbiology

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

bioRxiv · Jan 7, 2020Immunology

The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system

S. H. Becker, J. B. Jastrab, A. Dhabaria, C. Chaton, J. Rush, K. V. Korotkov, B. Ueberheide, K. H. Darwin

This study shows that the M. tuberculosis proteasome system regulates nitrate metabolism by controlling chaperonin gene expression through proteasome-mediated degradation of HrcA.

bioRxiv · Nov 14, 2018Microbiology

Cytokinin signaling in Mycobacterium tuberculosis

M. I. Samanovic, H.-C. Hsu, M. B. Jones, V. Jones, M. R. McNeil, S. H. Becker, A. T. Jordan, M. Strnad, C. Xu, M. Jackson, H. Li, K. H. Darwin

This study shows Mycobacterium tuberculosis uses cytokinins, previously known as plant hormones, to induce gene expression affecting its cell envelope.

bioRxiv · Jan 18, 2018Microbiology

Proteasome Substrate Capture and Gate Activation by Mycobacterium tuberculosis PafE

K. Hu, J. B. Jastrab, S. Zhang, A. Kovach, G. Zhao, K. H. Darwin, H. Li

This study identifies PafE as an ATP-independent proteasome activator in M. tuberculosis, revealing its mechanism of substrate capture and gate activation through structural and functional analyses.

bioRxiv · Jan 16, 2018Biochemistry