B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
J. B. Wong, S. L. Hewitt, L. M. Heltemes-Harris, M. Mandal, K. Johnson, K. Rajewsky, S. B. Koralov, M. R. Clark, M. A. Farrar, J. A. Skok
This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.
bioRxiv · Nov 13, 2017Immunology