M. R. Clark

Probabilistic ecological risk assessment for deep-sea mining: a Bayesian Network for Chatham Rise, SW Pacific Ocean

This paper applies Bayesian Networks to assess ecological risks of deep-sea mining on Chatham Rise, identifying uncertainties and informing policy decisions.

STAT3 signaling in B cells controls germinal center zone organization and recycling

This study shows STAT3 signaling in B cells controls germinal center zone organization and recycling, affecting long-lived plasma cell and memory B cell output.

In lupus nephritis, specific in situ inflammatory states are associated with refractory disease and progression to renal failure

Using deep machine learning to analyze confocal microscopy data, the study shows CD4-T cell populations in lupus nephritis organize into spatial neighborhoods predicting renal failure progression.

Intrarenal B cells integrate in situ innate and adaptive immunity in human renal allograft rejection

The paper identifies a unique B cell subset in renal allograft rejection that contributes to local inflammation through self-reactive antibodies and innate-like signaling.

In situ humoral selection in human lupus tubulointerstitial inflammation

The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.