Author

L. M. Heltemes-Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. A. Farrar· 3 shared R. S. LaRue· 2 shared S. A. Munro· 2 shared T. P. Knutson· 2 shared A. L. Sarver· 1 shared C. M. Henzler· 1 shared G. Hubbard· 1 shared J. A. Skok· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

M. A. Farrar

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3 papers

Recent·Most cited

Cancer BiologybioRxivNov 25, 2020

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

L. M. Heltemes-Harris, G. Hubbard, R. S. LaRue…·M. A. Farrar

This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.

DOI 10.1038/s41388-021-02012-z

mousebulk RNA-seq

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ImmunologybioRxivPreprintJun 30, 2020

Single-cell analysis of developing B cells reveals dynamic gene expression networks that govern B cell development and transformation

R. Lee, S. A. Munro, T. P. Knutson…·M. A. Farrar

The paper uses single-cell transcriptomics and proteomics to study B cell development, identifying novel proliferative phases and dynamic gene expression patterns linked to B cell transformation.

DOI 10.1101/2020.06.30.178301

mousescRNA-seq

𝕏 PostBluesky

ImmunologybioRxivNov 13, 2017

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

J. B. Wong, S. L. Hewitt, L. M. Heltemes-Harris…·J. A. Skok

This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.

DOI 10.1038/s41467-019-12824-z

mouseexperimental assay

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