Author

J. A. Skok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Tsirigos· 2 shared A. Heguy· 1 shared C. Do· 1 shared D. Dimartino· 1 shared D. Reinberg· 1 shared E. O. Mazzoni· 1 shared G. Cova· 1 shared G. Jiang· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. Tsirigos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MethNet: a robust approach to identify regulatory hubs and their distal targets in cancer

T. Sakellaropoulos, C. Do, G. Jiang, G. Cova, P. Meyn, D. Dimartino, S. Ramaswami, A. Heguy, A. Tsirigos, J. A. Skok

MethNet identifies regulatory hubs and their distal targets in cancer by integrating DNA methylation and gene expression data to uncover cis regulatory elements linked to patient survival.

bioRxiv · Jul 7, 2023 · PreprintCancer Biology

A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

H. Ortabozkoyun Kara, P.-Y. Huang, H. Cho, V. Narendra, G. LeRoy, J. A. Skok, A. Tsirigos, E. O. Mazzoni, D. Reinberg

The paper identifies MAZ as an insulator functioning at CTCF boundaries in Hox clusters, contributing to genomic architecture during differentiation.

bioRxiv · Aug 25, 2020Biochemistry

Rag1D600A, a novel catalytically inactive RAG mouse model

J. Wong, J. A. Skok

This paper introduces a novel Rag1D600A mouse model with impaired RAG activity, showing developmental blocks in B and T cell lineages.

bioRxiv · Jul 10, 2019 · PreprintImmunology

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

J. B. Wong, S. L. Hewitt, L. M. Heltemes-Harris, M. Mandal, K. Johnson, K. Rajewsky, S. B. Koralov, M. R. Clark, M. A. Farrar, J. A. Skok

This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.

bioRxiv · Nov 13, 2017Immunology