M. A. Farrar

Nuclear corepressors NCOR1 and NCOR2 entrain thymocytesignaling, selection, and emigration

This study shows NCOR1 and NCOR2 regulate thymocyte signaling, selection, and emigration, with combined deletion causing developmental blocks and altered signaling pathways.

Neoadjuvant systemic oncolytic vesicular stomatitis virus is safe and may enhance long-term survivorship in dogs with naturally occurring osteosarcoma.

This study evaluates neoadjuvant oncolytic virus therapy in dogs with osteosarcoma, finding it safe and associated with increased long-term survivorship and immune gene expression.

Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells

This study identifies two distinct regulatory T cell subsets in the lung during influenza infection and shows their role in modulating IgA+ B cells, with similar patterns observed in COVID-19 patients.

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.

Single-cell analysis of developing B cells reveals dynamic gene expression networks that govern B cell development and transformation

The paper uses single-cell transcriptomics and proteomics to study B cell development, identifying novel proliferative phases and dynamic gene expression patterns linked to B cell transformation.

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

This study shows that B-1a cells bypass the pre-BCR selection stage by developing in fetal liver with reduced IL-7R/STAT5 levels, leading to self-reactive BCRs.