CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1
L. Fort, J. Batista, P. A. Thomason, H. J. Spence, J. Greaves, K. J. Martin, K. I. Anderson, P. Brown, S. Lilla, M. P. Neilson, P. Tafelmeyer, S. Zanivan, S. Ismail, N. C. O. Tomkinson, L. H. Chamberlain, , L. M. Machesky
This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.
bioRxiv · Nov 29, 2017Cell Biology