Author

L. M. Machesky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. J. Spence· 3 shared R. H. Insall· 3 shared A. Juin· 2 shared C. Nixon· 2 shared K. J. Martin· 2 shared L. Fort· 2 shared P. A. Thomason· 2 shared S. Ismail· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

H. J. Spence

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

S. Nikolaou, A. Juin, J. A. Whitelaw, N. R. Paul, L. Fort, C. Nixon, H. J. Spence, S. Bryson, L. M. Machesky

The paper identifies CYRI-B as a mediator of macropinocytosis in pancreatic cancer, showing it suppresses metastasis by enabling lysophosphatidic acid receptor uptake.

bioRxiv · Nov 23, 2022Cancer Biology

Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

V. Papalazarou, J. Drew, A. Juin, H. J. Spence, C. Nixon, M. Salmeron-Sanchez, L. M. Machesky

The paper shows Collagen-VI is upregulated in pancreatic cancer cells on soft substrates and promotes metastasis by supporting the metastatic niche.

bioRxiv · Mar 3, 2022Cancer Biology

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

D. Newman, L. Young, T. Waring, L. Brown, K. Wolanska, E. MacDonald, A. Charles-Orszag, P. Caswell, T. Sakuma, T. Yamamoto, L. M. Machesky, M. Morgan, T. N. Zech

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

bioRxiv · May 17, 2021 · PreprintCell Biology

Seeing around corners: Cells create chemotactic gradients to solve mazes and respond to distant cues in complex environments.

L. Tweedy, P. Thomason, K. J. Martin, M. Zagnoni, L. M. Machesky, R. H. Insall

The paper shows cells use self-generated chemotactic gradients to navigate complex environments and solve mazes, with accuracy influenced by path complexity, attractant diffusibility, and cell speed.

bioRxiv · Nov 9, 2019 · PreprintCell Biology

WASP restricts active Rac to maintain cells’ front-rear polarisation

C. Amato, P. A. Thomason, A. J. Davidson, K. Swaminathan, S. Ismail, L. M. Machesky, R. H. Insall

This study shows WASP restricts active Rac to the front of cells to maintain front-rear polarity, but its interaction with Rac is not required for actin polymerization.

bioRxiv · Apr 10, 2019Cell Biology

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

L. Fort, J. Batista, P. A. Thomason, H. J. Spence, J. Greaves, K. J. Martin, K. I. Anderson, P. Brown, S. Lilla, M. P. Neilson, P. Tafelmeyer, S. Zanivan, S. Ismail, N. C. O. Tomkinson, L. H. Chamberlain, , L. M. Machesky

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.

bioRxiv · Nov 29, 2017Cell Biology