Author

H. J. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

L. M. Machesky· 3 shared A. Juin· 2 shared C. Nixon· 2 shared L. Fort· 2 shared J. A. Whitelaw· 1 shared J. Batista· 1 shared J. Drew· 1 shared J. Greaves· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

L. M. Machesky

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3 papers

Recent·Most cited

CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

S. Nikolaou, A. Juin, J. A. Whitelaw, N. R. Paul, L. Fort, C. Nixon, H. J. Spence, S. Bryson, L. M. Machesky

The paper identifies CYRI-B as a mediator of macropinocytosis in pancreatic cancer, showing it suppresses metastasis by enabling lysophosphatidic acid receptor uptake.

bioRxiv · Nov 23, 2022Cancer Biology

Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

V. Papalazarou, J. Drew, A. Juin, H. J. Spence, C. Nixon, M. Salmeron-Sanchez, L. M. Machesky

The paper shows Collagen-VI is upregulated in pancreatic cancer cells on soft substrates and promotes metastasis by supporting the metastatic niche.

bioRxiv · Mar 3, 2022Cancer Biology

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

L. Fort, J. Batista, P. A. Thomason, H. J. Spence, J. Greaves, K. J. Martin, K. I. Anderson, P. Brown, S. Lilla, M. P. Neilson, P. Tafelmeyer, S. Zanivan, S. Ismail, N. C. O. Tomkinson, L. H. Chamberlain, , L. M. Machesky

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.

bioRxiv · Nov 29, 2017Cell Biology