Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation
K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C. J. Neufeldt, M. Cortese, B. Cerikan, C. S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, , R. Bartenschlager
This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.
bioRxiv · May 10, 2021Microbiology