L. Adam

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.

An integrated transcriptomic cell atlas of human endoderm-derived organoids

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

Human intestinal organoids with an autologoustissue-resident immune compartment

This study develops human intestinal immuno-organoids (IIOs) that integrate tissue-resident immune cells, enabling the study of intestinal inflammation and immune responses in disease contexts.

A social media-based framework for quantifying temporal changes to wildlife viewing intensity: Case study of sea turtles before and during COVID-19

The paper develops a social media-based framework to quantify changes in wildlife viewing pressure over time, applied to sea turtles before and during the COVID-19 pandemic.

LOX-1+ immature neutrophils predict severe COVID-19 patients at risk of thrombotic complications

Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins

This study investigates the structural and functional role of a secondary iron-binding site in encapsulated ferritins using enzymatic assays, mass-spectrometry, and X-ray crystallography.

Automated screening by 3D light-sheet microscopy with high spatial and temporal resolution reveals mitotic phenotypes

The paper presents a workflow using 3D light-sheet microscopy and automated image processing to screen mitotic phenotypes in 3D cell cultures with high throughput.