Author

J. Biernaskie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

S. Sinha· 3 shared A. Dufour· 2 shared A. Jaffer· 2 shared B. Yipp· 2 shared E. Labit· 2 shared N. L. Rosin· 2 shared R. Arora· 2 shared A. Bromley· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

S. Sinha

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

G. A. Gonzales, S. Huang, J. Rajwani, L. Wilkinson, J. A. Nguyen, C. M. Wood, I. Dinh, M. Moore, E. Cedeno, S. Sikdar, N. McKenna, V. Ebacher, N. L. Rosin, M. B. Carneiro, B. Surewaard, , J. Canton

This study identifies APOL7C as a pore-forming protein that facilitates phagosomal rupture and antigen cross-presentation by cDC1s.

bioRxiv · Aug 11, 2023Cell Biology

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

R. Arora, C. Cao, M. Kumar, S. Sinha, A. Chanda, R. McNeil, D. Samuel, R. K. Arora, T. W. Matthew, S. Chandarana, R. Hart, J. C. Dort, J. Biernaskie, P. Neri, M. D. Hyrcza, P. Bose

This study uses spatial transcriptomics to analyze tumor core and edge regions in OSCC, revealing distinct transcriptional profiles and their clinical implications across multiple cancers.

bioRxiv · Sep 4, 2022Cancer Biology

An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy

S. Sinha, N. Rosin, R. Arora, E. Labit, A. Jaffer, L. Cao, R. Farias, A. P. Nguyen, L. G. N. de Almeida, A. Dufour, A. Bromley, B. McDonald, M. Gillrie, M. J. Fritzler, B. Yipp, J. Biernaskie

This study identifies distinct neutrophil states in COVID-19 compared to bacterial ARDS and shows dexamethasone alters these states, reducing mortality risk.

bioRxiv · Apr 18, 2021Immunology

SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients

N. L. Rosin, A. Jaffer, S. Sinha, R. P. Mulloy, C. Robinson, E. Labit, L. G. Almeida, A. Dufour, J. A. Corcoran, B. Yipp, J. Biernaskie

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

bioRxiv · Jan 19, 2021 · PreprintImmunology