Author

R. P. Mulloy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

J. A. Corcoran· 2 shared M. P. Bui-Marinos· 2 shared S. Mubareka· 2 shared A. Ariana· 1 shared A. Banerjee· 1 shared A. Dufour· 1 shared A. Finzi· 1 shared A. Jaffer· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

J. A. Corcoran

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

E. S. Pringle, B. A. Duguay, M. P. Bui-Marinos, R. P. Mulloy, S. L. Landreth, K. S. Desireddy, S. M. Dolliver, S. Ying, T. Caddell, P. D. Slaine, S. L. Bearne, D. Falzarano, J. Corcoran, D. A. Khaperskyy, C. McCormick

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

bioRxiv · Mar 10, 2022Microbiology

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

M. Benlarbi, G. Laroche, C. Fink, K. Fu, R. P. Mulloy, A. Phan, A. Ariana, C. M. Stewart, J. Prevost, G. Beaudoin-Bussieres, R. Daniel, Y. Bo, J. Yockell-Lelievre, W. L. Stanford, P. M. Giguere, , M. Cote

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

bioRxiv · Feb 19, 2022Microbiology

SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients

N. L. Rosin, A. Jaffer, S. Sinha, R. P. Mulloy, C. Robinson, E. Labit, L. G. Almeida, A. Dufour, J. A. Corcoran, B. Yipp, J. Biernaskie

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

bioRxiv · Jan 19, 2021 · PreprintImmunology

Human coronaviruses disassemble processing bodies

M. Kleer, R. P. Mulloy, C.-A. Robinson, D. Evseev, M. P. Bui-Marinos, E. L. Castle, A. Banerjee, S. Mubareka, K. Mossman, J. A. Corcoran

This study shows SARS-CoV-2 and related coronaviruses induce processing body disassembly, with SARS-CoV-2's N protein uniquely causing this effect, leading to increased proinflammatory cytokine production.

bioRxiv · Nov 8, 2020Microbiology