Mechanism by which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency
N. Sluis-Cremer, B. Vargas, N. A. Yates, J. Boslett
This study identifies PF-3758309 as a PAK inhibitor that blocks HIV-1 latency reversal by downregulating NF-κB signaling, with PAK1 and PAK2 playing key roles in latency maintenance.
bioRxiv · Aug 2, 2022Microbiology